Potassium Hydroxide → HCID 178419357, compound

HRID 1421716Notes

Reaction equation

HRID 1421716 reaction equation
Cl.Cl.[NH2:3][CH2:4][CH2:5][C:6]1[N:10]=[CH:9][NH:8][CH:7]=1.[OH-].[K+].[Br:13][C:14]1[CH:21]=[CH:20][C:17]([CH:18]=O)=[CH:16][CH:15]=1>O.CCO>[Br:13][C:14]1[CH:21]=[CH:20][C:17]([CH:18]2[C:7]3[NH:8][CH:9]=[N:10][C:6]=3[CH2:5][CH2:4][NH:3]2)=[CH:16][CH:15]=1

Participants

6

Reactant 3

HCID 14797Potassium HydroxideHCID 707414-BromobenzaldehydeHCID 178478691HCID 178478691, compound

Product 1

HCID 178419357HCID 178419357, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

Histamine dihydrochloride (3.68 g, 0.02 mole), KOH (3.36 g, 0.06 mole), and 4-bromobenzaldehyde were dissolved in water (250 mL) and 95% EtOH(100 mL). The reaction was heated for 24 h at reflux while being open to the atmosphere. The resulting white precipitate was filtered and dried under vacuum at 40° C. to give the title compound.

Workup

  1. temperatureThe reaction was heated for 24 h
  2. temperatureat reflux
  3. filtrationThe resulting white precipitate was filtered
  4. customdried under vacuum at 40° C.

Sources & evidence

ORD record
ord-eaadd16f9e704579ba0cc5b61ee93e65
Source dataset
uspto-grants-2000_06
Patent number
US06077853

Reaction notes

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