反应详情

温度

70 °C

4-cyano-3-hydroxybenzoic acid methyl ester, Example 34, Step 3 (2.5 g, 14 mmol) was dissolved in THF (70 ml). LiBH4 in THF (2 M, 14 ml, 28 mmol) was added. The reaction mixture was heated to 70° C. for 60 hrs. The reaction mixture was quenched carefully with 3N HCl. The solvent was removed in vacuo and the crude material was purified by flash chromatography [10% MeOH(5% NH4OH)/CH2Cl2 ] to yield the desired product.

1. customThe reaction mixture was quenched carefully with 3N HCl
2. customThe solvent was removed in vacuo
3. customthe crude material was purified by flash chromatography [10% MeOH(5% NH4OH)/CH2Cl2 ]