HCID 15458389, compound → HCID 18706835, compound

HRID 1421870Notes

Reaction equation

HRID 1421870 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([NH2:8])[N:5]=[C:4]([NH:9][CH2:10][CH2:11][CH2:12][OH:13])[C:3]=1[NH2:14].[ClH:15].CO>CO>[ClH:1].[ClH:15].[Cl:1][C:2]1[N:7]=[C:6]([NH2:8])[N:5]=[C:4]([NH:9][CH2:10][CH2:11][CH2:12][OH:13])[C:3]=1[NH2:14]

Participants

4

Reactant 2

HCID 15458389HCID 15458389, compoundHCID 21893726Hydrochloride methanol

Product 1

HCID 18706835HCID 18706835, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

6-Chloro-2,5-diamino-4-[(3-hydroxypropyl)amino]pyrimidine (0.290 g, 1.0 mmol) was dissolved in 20 ml of methanol, and 3 equivalents of 14% HCl-methanol solution was carefully added under ice-cooling. The mixture was warmed to room temperature and the solvent was distilled away to give white crystals (0.26 g, 90.0%), m.p. 120-131° C. (ether).

Workup

  1. temperaturecooling
  2. distillationthe solvent was distilled away

Sources & evidence

ORD record
ord-361d8a5c366440e89291776120a5d138
Source dataset
uspto-grants-2000_06
Patent number
US06080750

Reaction notes

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