Ethanol → HCID 385223, compound

HRID 1421871Notes

Reaction equation

HRID 1421871 reaction equation
OC[CH:3]([NH2:8])[CH:4]1[CH2:7][CH2:6][CH2:5]1.[NH2:9][C:10]1[N:15]=[C:14](Cl)[CH:13]=[C:12]([Cl:17])[N:11]=1.[CH2:18]([OH:20])C>C(N(CC)CC)C>[NH2:9][C:10]1[N:15]=[C:14]([NH:8][CH2:3][C:4]2([CH2:18][OH:20])[CH2:5][CH2:6][CH2:7]2)[CH:13]=[C:12]([Cl:17])[N:11]=1

Participants

5

Reactant 3

HCID 702EthanolHCID 655222-Amino-4,6-dichloropyrimidineHCID 15458387HCID 15458387, compound

Product 1

HCID 385223HCID 385223, compoundYield 92.3%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

A mixture of 1-hydroxymethyl-1-cyclobutylmethylamine (5.75 g, 0.05 mol), 2-amino-4,6-dichloropyrimidine (8.20 g, 0.05 mol), ethanol (200 ml) and triethylamine (20 ml) was refluxed for one day. The solvent was distilled away under reduced pressure. The residue was washed with water, dried and recrystallized from acetone to give colorless prism crystals (11.2 g, 92.3%), m.p. 192-194° C. (acetone).

Workup

  1. temperaturewas refluxed for one day
  2. distillationThe solvent was distilled away under reduced pressure
  3. washThe residue was washed with water
  4. customdried
  5. customrecrystallized from acetone

Sources & evidence

ORD record
ord-2da758854a624c0887b4f377db1896d1
Source dataset
uspto-grants-2000_06
Patent number
US06080750

Reaction notes

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