1,2-Dichlorobenzene → HCID 18707312, compound

HRID 1421969Notes

Reaction equation

HRID 1421969 reaction equation
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([C:13]2[S:14][CH:15]=[C:16]([C:18]3[CH:23]=[CH:22][C:21]([O:24]CC=C)=[C:20]([C:28]([O:30][CH3:31])=[O:29])[CH:19]=3)[N:17]=2)[CH:7]=[CH:8][C:9]=1[O:10][CH2:11][CH3:12])[CH3:2].Cl[C:33]1[CH:38]=CC=C[C:34]=1Cl>>[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([C:13]2[S:14][CH:15]=[C:16]([C:18]3[CH:23]=[C:22]([CH2:38][CH:33]=[CH2:34])[C:21]([OH:24])=[C:20]([C:28]([O:30][CH3:31])=[O:29])[CH:19]=3)[N:17]=2)[CH:7]=[CH:8][C:9]=1[O:10][CH2:11][CH3:12])[CH3:2]

Participants

3

Reactant 2

HCID 72391,2-DichlorobenzeneHCID 18707198HCID 18707198, compound

Product 1

HCID 18707312HCID 18707312, compound

Procedure

A solution of 1 g of 2-(3,4-diethoxyphenyl)-4-(4-allyloxy-3-methoxycarbonylphenyl)thiazole in 25 ml of o-dichlorobenzene was refluxed for 15 hours with heating. After the completion of a reaction, the solvent was removed by distillation. The residue was recrystallized from diisopropyl ether to obtain 1 g of 2-(3,4-diethoxyphenyl)-4-(3-methoxycarbonyl-4-hydroxy-5-allylphenyl)thiazole.

Workup

  1. temperaturewith heating
  2. customAfter the completion of a reaction
  3. customthe solvent was removed by distillation
  4. customThe residue was recrystallized from diisopropyl ether

Sources & evidence

ORD record
ord-403e62e48f774194a77d5b0122c73c94
Source dataset
uspto-grants-2000_06
Patent number
US06080764

Reaction notes

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