HCID 848930, compound → HCID 978141, compound

HRID 1422019Notes

Reaction equation

HRID 1422019 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10]([NH:12][NH:13][C:14]([C:16]2[S:17][CH:18]=[CH:19][CH:20]=2)=O)=[S:11])=[CH:5][CH:4]=1.[O-]CC.[Na+]>C(O)C>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:14]([C:16]3[S:17][CH:18]=[CH:19][CH:20]=3)=[N:13][NH:12][C:10]2=[S:11])=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 848930HCID 848930, compoundHCID 2723922Sodium ethoxide

Product 1

HCID 978141HCID 978141, compoundYield 63.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

N1-(4-Methoxyphenylaminothiocarbonyl)-N2-(thien-2-carbonyl)hydrazine (1 g) and 0.2 g of sodium ethoxide in 10 mL of ethanol are refluxed for 6 hours. The mixture is cooled and the precipitate collected by vacuum filtration and dried to give 0.6 g of the title compound as an off-white solid. 4-(4-Methoxyphenyl)-5-(thien-2-yl)-1,2,4-triazol-3-thione (0.5 g) and 0.4 g of 2-bromo-5-nitrothiazole in 50 mL of acetonitrile are refluxed for 6 hours. The solvent is concentrated to give crude product which is collected by vacuum filtration. The crude product is crystallized from ethanol and dried to give 0.6 g of the desired triazole compound as an off-white solid.

Workup

  1. temperatureThe mixture is cooled
  2. filtrationthe precipitate collected by vacuum filtration
  3. customdried

Sources & evidence

ORD record
ord-7fa89252e97e420284332ffbbb932178
Source dataset
uspto-grants-2000_06
Patent number
US06080772

Reaction notes

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