Phenyl Isothiocyanate → HCID 4608870, compound

HRID 1422021Notes

Reaction equation

HRID 1422021 reaction equation
[C:1]1([N:7]=[C:8]=[S:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.COC1C=CC(N=C=S)=CC=1.[NH:21]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[C:23]([CH2:30][C:31]([NH:33][NH2:34])=[O:32])=[CH:22]1>>[C:1]1([NH:7][C:8]([NH:34][NH:33][C:31](=[O:32])[CH2:30][C:23]2[C:24]3[C:29](=[CH:28][CH:27]=[CH:26][CH:25]=3)[NH:21][CH:22]=2)=[S:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 3

HCID 7673Phenyl IsothiocyanateHCID 215893-Indoleacetic acid hydrazideHCID 752934-Methoxyphenyl isothiocyanate

Product 1

HCID 4608870HCID 4608870, compoundYield 72.9%

Procedure

By substituting 1.5 g of phenylisothiocyanate for the 4-methoxyphenylisothiocyanate and 2 g of 2-(indol-3-yl)acetic acid hydrazide for the thien-2-carboxyhydrazide in the method of Example 97, 2.5 g of the title compound is obtained as an off-white solid.

Sources & evidence

ORD record
ord-3dff98bc041f482db575b21ca2da6e0d
Source dataset
uspto-grants-2000_06
Patent number
US06080772

Reaction notes

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