Hydrochloric Acid → HCID 54183164, compound

HRID 1422035Notes

Reaction equation

HRID 1422035 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[CH2:7][CH2:6][CH2:5]2.[OH:13][C:14]1[CH:15]=[C:16]([CH:19]=[CH:20][C:21]=1[OH:22])[CH:17]=O.Cl.CO>O>[OH:13][C:14]1[CH:15]=[C:16]([CH:17]=[C:7]2[CH2:6][CH2:5][C:4]3[C:9](=[CH:10][CH:11]=[C:2]([OH:1])[CH:3]=3)[C:8]2=[O:12])[CH:19]=[CH:20][C:21]=1[OH:22]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 87683,4-DihydroxybenzaldehydeHCID 46794946-Hydroxy-3,4-dihydro-1(2H)-naphthalenone

Product 1

HCID 54183164HCID 54183164, compoundYield 72%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

After 6-hydroxy-1-tetralone 1.0 g and 3,4-dihydroxybenzaldehyde 0.85 g were added to a mixture of concentrated hydrochloric acid 50 ml and methanol 75 ml, the mixture was refluxed for 2.5 hours and cooled to room temperature, and water 357 ml was added. The precipitated crystals were filtered. The crystals were dried over phosphorous pentoxide for six hours under reduced pressure to obtain the desired compound 1.25 g.

Workup

  1. temperaturethe mixture was refluxed for 2.5 hours
  2. filtrationThe precipitated crystals were filtered
  3. dry with materialThe crystals were dried over phosphorous pentoxide for six hours under reduced pressure

Sources & evidence

ORD record
ord-9b3d48d966704a5892c524124dec01b7
Source dataset
uspto-grants-2000_06
Patent number
US06080781

Reaction notes

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