Hydrochloric Acid → HCID 54285327, compound

HRID 1422040Notes

Reaction equation

HRID 1422040 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[CH2:7][CH2:6][CH2:5]2.[CH3:13][O:14][C:15]1[CH:16]=[C:17]([CH:20]=[CH:21][C:22]=1[O:23][CH3:24])[CH:18]=O.Cl>CO>[CH3:13][O:14][C:15]1[CH:16]=[C:17]([CH:18]=[C:7]2[CH2:6][CH2:5][C:4]3[C:9](=[CH:10][CH:11]=[C:2]([OH:1])[CH:3]=3)[C:8]2=[O:12])[CH:20]=[CH:21][C:22]=1[O:23][CH3:24]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 8419VeratraldehydeHCID 46794946-Hydroxy-3,4-dihydro-1(2H)-naphthalenone

Product 1

HCID 54285327HCID 54285327, compoundYield 83.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

After 6-hydroxy-1-tetralone 1.0 g and 3,4-dimethoxybenzaldehyde 1.23 g were added to a mixture of concentrated hydrochloric acid 50 ml and methanol 75 ml, the mixture was refluxed for 1.5 hours and cooled to room temperature, and the precipitated crystals were filtered. The crystals were dried over phosphorous pentoxide for 5.5 hours under reduced pressure to obtain the desired compound 1.60 g.

Workup

  1. temperaturethe mixture was refluxed for 1.5 hours
  2. filtrationthe precipitated crystals were filtered
  3. dry with materialThe crystals were dried over phosphorous pentoxide for 5.5 hours under reduced pressure

Sources & evidence

ORD record
ord-11d4a80d408341eaaae1500f04617e90
Source dataset
uspto-grants-2000_06
Patent number
US06080781

Reaction notes

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