Hydrochloric Acid → HCID 54352714, compound

HRID 1422041Notes

Reaction equation

HRID 1422041 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[CH2:7][CH2:6][CH2:5]2.[CH3:13][O:14][C:15]1[CH:16]=[C:17]([CH:20]=[C:21]([O:23][CH3:24])[CH:22]=1)[CH:18]=O.Cl>CO>[CH3:24][O:23][C:21]1[CH:20]=[C:17]([CH:18]=[C:7]2[CH2:6][CH2:5][C:4]3[C:9](=[CH:10][CH:11]=[C:2]([OH:1])[CH:3]=3)[C:8]2=[O:12])[CH:16]=[C:15]([O:14][CH3:13])[CH:22]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 817473,5-DimethoxybenzaldehydeHCID 46794946-Hydroxy-3,4-dihydro-1(2H)-naphthalenone

Product 1

HCID 54352714HCID 54352714, compoundYield 66.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

After 6-hydroxy-1-tetralone 1.0 g and 3,5-dimethoxybenzaldehyde 1.23 g were added to a mixture of concentrated hydrochloric acid 50 ml and methanol 75 ml, the mixture was refluxed for 1.5 hours and cooled to room temperature, and the precipitated crystals were filtered. The crystals were dried over phosphorous pentoxide for four hours under reduced pressure to obtain the desired compound 1.276 g.

Workup

  1. temperaturethe mixture was refluxed for 1.5 hours
  2. filtrationthe precipitated crystals were filtered
  3. dry with materialThe crystals were dried over phosphorous pentoxide for four hours under reduced pressure

Sources & evidence

ORD record
ord-7dc438361e034f1d87c3ff47f396f03c
Source dataset
uspto-grants-2000_06
Patent number
US06080781

Reaction notes

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