Hydrochloric Acid → HCID 54086101, compound

HRID 1422045Notes

Reaction equation

HRID 1422045 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[CH2:7][CH2:6][CH2:5]2.[CH:13]1[C:18]([CH:19]=O)=[CH:17][C:16]2[O:21][CH2:22][O:23][C:15]=2[CH:14]=1.Cl>CO>[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[C:7](=[CH:19][C:18]1[CH:13]=[CH:14][C:15]3[O:23][CH2:22][O:21][C:16]=3[CH:17]=1)[CH2:6][CH2:5]2

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 8438PiperonalHCID 46794946-Hydroxy-3,4-dihydro-1(2H)-naphthalenone

Product 1

HCID 54086101HCID 54086101, compoundYield 89.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

After 6-hydroxy-1-tetralone 1.0 g and piperonal 1.11 g were added to a mixture of concentrated hydrochloric acid 50 ml and methanol 75 ml, the mixture was refluxed for 0.5 hours and cooled to room temperature, and the precipitated crystals were filtered. The crystals were dried over phosphorous pentoxide for four hours under reduced pressure to obtain the desired compound 1.63 g.

Workup

  1. temperaturethe mixture was refluxed for 0.5 hours
  2. filtrationthe precipitated crystals were filtered
  3. dry with materialThe crystals were dried over phosphorous pentoxide for four hours under reduced pressure

Sources & evidence

ORD record
ord-5d7de11b8d7a41698f861c8cbb50db81
Source dataset
uspto-grants-2000_06
Patent number
US06080781

Reaction notes

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