HCID 10716098, compound → HCID 10730616, compound

HRID 1422059Notes

Reaction equation

HRID 1422059 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[CH:10]([OH:30])[CH:11]([NH:19]C(OCC1C=CC=CC=1)=O)[CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>CO.[C].[Pd]>[NH2:19][CH:11]([CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH:10]([C:2]1[O:1][C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=1)[OH:30]

Participants

4

Reactant 1

HCID 10716098HCID 10716098, compound

Product 1

HCID 10730616HCID 10730616, compoundYield 100.4%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

To a solution of the objective compound (3.63 g, 9.02 mmol) of Step (4) in methanol (50 mL) was added under nitrogen atmosphere 10% palladium carbon (480 mg) and the mixture was stirred at room temperature for 18 hours under hydrogen atmosphere. The catalyst was filtered off and washed with methanol. The filtrate was concentrated under reduced pressure to give the title compound as a brown solid (2.43 g, 100%).

Workup

  1. filtrationThe catalyst was filtered off
  2. washwashed with methanol
  3. concentrationThe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-3d0e45286566492bb3bf85a8b88543ba
Source dataset
uspto-grants-2000_06
Patent number
US06080738

Reaction notes

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