HCID 54045910, compound → HCID 53974404, compound

HRID 1422093Notes

Reaction equation

HRID 1422093 reaction equation
[CH3:1][N:2]([CH3:32])[C:3]([C:5]1[C:13]2=[C:14]([C:18]3[CH:23]=[CH:22][C:21]([O:24]CC4C=CC=CC=4)=[CH:20][CH:19]=3)[C:15]([CH2:16][CH3:17])=[C:11]3[N:12]2[C:7](=[CH:8][CH:9]=[CH:10]3)[CH:6]=1)=[O:4]>C(O)C>[CH3:32][N:2]([CH3:1])[C:3]([C:5]1[C:13]2=[C:14]([C:18]3[CH:19]=[CH:20][C:21]([OH:24])=[CH:22][CH:23]=3)[C:15]([CH2:16][CH3:17])=[C:11]3[N:12]2[C:7](=[CH:8][CH:9]=[CH:10]3)[CH:6]=1)=[O:4]

Participants

3

Reactant 1

HCID 54045910HCID 54045910, compound

Product 1

HCID 53974404HCID 53974404, compoundYield 113%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4-Ethyl-3-(4-benzyloxyphenyl)pyrrolo[2,1,5-cd]indolizine-2-carboxylic acid dimethlamide was hydrogenated by the general synthetic principles outlined in example 12, to afford 4-ethyl-3-(4-hydroxyphenyl)pyrrolo[2,1,5-cd]indolizine-2-carboxylic acid dimethylamide as a yellow gum in 113% yield (ethanol incl.). 1H-NMR (CDCl3, 300 MHz) δ: 1.43 (t, 3H); 2.56 (s, 3H); 2.98 (s, 3H); 3.19 (q, 2H); 7.00 (d, 2H); 7.33 (s, 1H); 7.49 (d, 2H); 7.68 (dd, 1H); 7.96 (d, 2H).

Sources & evidence

ORD record
ord-6766a20ac61e41a292f5fd0c97383b9e
Source dataset
uspto-grants-2000_06
Patent number
US06080754

Reaction notes

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