Hydrochloric Acid → HCID 21022648, compound

HRID 1422185Notes

Reaction equation

HRID 1422185 reaction equation
[OH:1][N:2]1[C:7]([CH3:9])([CH3:8])[CH2:6][CH:5]([O:10][CH2:11][C:12]([O:14]CC)=[O:13])[CH2:4][C:3]1([CH3:18])[CH3:17].[OH-].[Na+].Cl>O.CO>[OH:1][N:2]1[C:7]([CH3:9])([CH3:8])[CH2:6][CH:5]([O:10][CH2:11][C:12]([OH:14])=[O:13])[CH2:4][C:3]1([CH3:18])[CH3:17]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 69035975HCID 69035975, compound

Product 1

HCID 21022648HCID 21022648, compound

Reagents, catalysts & solvents 1

HCID 22242641Methanol--water (1/1)Solvent

Procedure

1.0 g (39 mmol) of the compound of Example 6 is added to a solution of 0.2 g sodium hydroxide in 20 mL of 1:1 water/methanol. The mixture is stirred for one hour, carefully acidified with 1% aqueous hydrogen chloride and then extracted with ethyl acetate. The organic extract is dried over anhydrous magnesium sulfate and then contentrated to afford the title compound as an orange solid.

Workup

  1. extractionextracted with ethyl acetate
  2. extractionThe organic extract
  3. dry with materialis dried over anhydrous magnesium sulfate

Sources & evidence

ORD record
ord-77cca853a6404ce49f25a0cd54abd809
Source dataset
uspto-grants-2000_06
Patent number
US06080864

Reaction notes

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