HCID 18706304, compound → HCID 18706766, compound

HRID 1422207Notes

Reaction equation

HRID 1422207 reaction equation
C([O:5][C:6](=[O:25])[CH2:7][NH:8][CH2:9][C:10]1[CH:19]=[C:18]([Br:20])[CH:17]=[C:16]2[C:11]=1[N:12]=[C:13]([O:23]C)[C:14]([O:21]C)=[N:15]2)(C)(C)C>Br.C(O)(=O)C.C(OCC)C>[BrH:20].[Br:20][C:18]1[CH:17]=[C:16]2[C:11]([NH:12][C:13](=[O:23])[C:14](=[O:21])[NH:15]2)=[C:10]([CH2:9][NH:8][CH2:7][C:6]([OH:25])=[O:5])[CH:19]=1

Participants

5

Reactant 1

HCID 18706304HCID 18706304, compound

Product 1

HCID 18706766HCID 18706766, compound

Reagents, catalysts & solvents 3

HCID 176Acetic AcidSolventHCID 260Hydrogen BromideSolventHCID 3283Diethyl EtherSolvent

Conditions

Temperature
70 °C

Procedure

380 mg (0.921 mmol) of N-(7-bromo-2,3-dimethoxy-quinoxalin-5-ylmethyl)-glycine tert-butyl ester are dissolved in 6 ml of an approximately 25% solution of hydrogen bromide in acetic acid and the solution is stirred for two hours at 70° C. The mixture is cooled to 20° C. and diluted with diethyl ether. The solid is filtered off and washed with diethyl ether. After drying under a high vacuum, the title compound is obtained in the form of a white powder.

Workup

  1. temperatureThe mixture is cooled to 20° C.
  2. filtrationThe solid is filtered off
  3. washwashed with diethyl ether
  4. customAfter drying under a high vacuum

Sources & evidence

ORD record
ord-f24127a404e94209a09e1c1803deae49
Source dataset
uspto-grants-2000_06
Patent number
US06080743

Reaction notes

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