Hydrochloric Acid → HCID 18706388, compound

HRID 1422216Notes

Reaction equation

HRID 1422216 reaction equation
Br.C([O:4][C:5]([CH:7]1[CH2:12][CH2:11][N:10]([CH2:13][C:14]2[CH:23]=[C:22]([Br:24])[CH:21]=[C:20]3[C:15]=2[NH:16][C:17](=[O:26])[C:18](=[O:25])[NH:19]3)[CH2:9][CH2:8]1)=[O:6])C.Cl>[OH-].[Na+]>[Br:24][C:22]1[CH:21]=[C:20]2[C:15]([NH:16][C:17](=[O:26])[C:18](=[O:25])[NH:19]2)=[C:14]([CH2:13][N:10]2[CH2:11][CH2:12][CH:7]([C:5]([OH:6])=[O:4])[CH2:8][CH2:9]2)[CH:23]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 70272035HCID 70272035, compound

Product 1

HCID 18706388HCID 18706388, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

1.28 g (3.12 mmol) of N-(7-bromo-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-ylmethyl)-piperidine-4-carboxylic acid ethyl ester hydrobromide (penultimate compound in Example 2) are stirred at 20° C. for 16 hours in 12 ml of 2N sodium hydroxide solution. The mixture is acidified with 2N hydrochloric acid, and the resulting solid is filtered off and washed with water and diethyl ether. The title compound is obtained in the form of a white solid.

Workup

  1. filtrationthe resulting solid is filtered off
  2. washwashed with water and diethyl ether

Sources & evidence

ORD record
ord-6a00095d3a694cd2a87b33afc146b86f
Source dataset
uspto-grants-2000_06
Patent number
US06080743

Reaction notes

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