Water → HCID 18706342, compound

HRID 1422218Notes

Reaction equation

HRID 1422218 reaction equation
[N-:1]=[N+:2]=[N-:3].[Na+].[Br:5][C:6]1[CH:15]=[C:14]2[C:9]([N:10]=[C:11]([O:18][CH3:19])[C:12]([O:16][CH3:17])=[N:13]2)=[C:8]([CH2:20]Br)[CH:7]=1.O>CN(C)C=O>[N:1]([CH2:20][C:8]1[CH:7]=[C:6]([Br:5])[CH:15]=[C:14]2[C:9]=1[NH:10][CH:11]([O:18][CH3:19])[CH:12]([O:16][CH3:17])[NH:13]2)=[N+:2]=[N-:3]

Participants

5

Reactant 3

HCID 962WaterHCID 33557Sodium AzideHCID 23298010HCID 23298010, compound

Product 1

HCID 18706342HCID 18706342, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

743 mg (2 equiv.) of sodium azide are added at 20° C. to 2.07 g (5.72 mmol) of 7-bromo-5-bromomethyl-2,3-dimethoxy-quinoxaline in 25 ml of dimethylformamide. After 3 hours, the mixture is poured into water, extracted with diethyl ether, washed with water and brine and dried with magnesium sulfate. The solvent is concentrated by evaporation.

Workup

  1. extractionextracted with diethyl ether
  2. washwashed with water and brine
  3. dry with materialdried with magnesium sulfate
  4. concentrationThe solvent is concentrated by evaporation

Sources & evidence

ORD record
ord-4c0138fec2b24723b437e1bc47e03591
Source dataset
uspto-grants-2000_06
Patent number
US06080743

Reaction notes

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