Water → HCID 53927376, compound

HRID 1422221Notes

Reaction equation

HRID 1422221 reaction equation
C([O:3][C:4](=[O:24])[CH:5]=[CH:6][C:7](=[O:23])[NH:8][CH2:9][C:10]1[CH:19]=[C:18]([Br:20])[CH:17]=[C:16]2[C:11]=1[NH:12][C:13](=[O:22])[C:14](=[O:21])[NH:15]2)C.O.[OH-].[Li+].O>O1CCCC1.O>[Br:20][C:18]1[CH:17]=[C:16]2[C:11]([NH:12][C:13](=[O:22])[C:14](=[O:21])[NH:15]2)=[C:10]([CH2:9][NH:8][C:7]([CH:6]=[CH:5][C:4]([OH:24])=[O:3])=[O:23])[CH:19]=1

Participants

5

Reactant 3

HCID 962WaterHCID 168937Lithium hydroxide, monohydrateHCID 54239092HCID 54239092, compound

Product 1

HCID 53927376HCID 53927376, compound

Reagents, catalysts & solvents 1

HCID 21881883Oxolane--water (1/1)Solvent

Procedure

144 mg (0.36 mmol) of 3-[(7-bromo-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-ylmethyl)-carbamoyl]-acrylic acid ethyl ester (Example 10) and 76 mg of lithium hydroxide hydrate are dissolved in 18 ml of tetrahydrofuran/water (2:1) and the solution is stirred for 18 hours. 50 ml of water are added, the tetrahydrofuran is concentrated by evaporation and the solution is acidified with 1 N hydrochloric acid. The solid is filtered off, washed with water and dried.

Workup

  1. concentrationthe tetrahydrofuran is concentrated by evaporation
  2. filtrationThe solid is filtered off
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-e0eb2b2da8ec42e688511afacfd80e93
Source dataset
uspto-grants-2000_06
Patent number
US06080743

Reaction notes

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