反应详情

200 mg of 5-bromomethyl-2,3-dimethoxy-7-nitro-quinoxaline and 0.016 ml (2.2 equiv.) of N-benzyl-methylamine are dissolved in 10 ml of acetonitrile, and the solution is stirred at reflux for 20 hours. The mixture is concentrated by evaporation, and the residue is dissolved in ethyl acetate and washed in aqueous 5% sodium carbonate solution and brine. The organic phase is dried over magnesium sulfate and the solvent is concentrated by evaporation.

1. temperatureat reflux for 20 hours
2. concentrationThe mixture is concentrated by evaporation
3. dissolutionthe residue is dissolved in ethyl acetate
4. washwashed in aqueous 5% sodium carbonate solution and brine
5. dry with materialThe organic phase is dried over magnesium sulfate
6. concentrationthe solvent is concentrated by evaporation