Hydrochloric Acid → HCID 70272797, compound

HRID 1422235Notes

Reaction equation

HRID 1422235 reaction equation
Br.C([O:4][C:5](=[O:29])[CH2:6][C:7]1[N:8]([CH2:13][C:14]2[CH:23]=[C:22]([N+:24]([O-:26])=[O:25])[CH:21]=[C:20]3[C:15]=2[NH:16][C:17](=[O:28])[C:18](=[O:27])[NH:19]3)[CH:9]([NH2:12])[S:10][CH:11]=1)C.[ClH:30]>[OH-].[Na+]>[ClH:30].[O:27]=[C:18]1[C:17](=[O:28])[NH:16][C:15]2[C:20](=[CH:21][C:22]([N+:24]([O-:26])=[O:25])=[CH:23][C:14]=2[CH2:13][N:8]2[C:7]([CH2:6][C:5]([OH:29])=[O:4])=[CH:11][S:10][CH:9]2[NH2:12])[NH:19]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 70271850HCID 70271850, compound

Product 1

HCID 70272797HCID 70272797, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

80 mg (0.2 mmol) of [N-(2,3-dioxo-7-nitro-1,2,3,4-tetrahydroquinoxalin-5-ylmethyl)-2-amino-4-thiazolyl]-acetic acid ethyl ester hydrobromide are stirred in 2 ml of 2N sodium hydroxide solution at room temperature for 16 hours. The mixture is acidified with 3N HCl, and the resulting solid is filtered off and washed with a small amount of water and 2×20 ml of diethyl ether. After drying, the title compound is obtained in the form of a yellow solid.

Workup

  1. filtrationthe resulting solid is filtered off
  2. washwashed with a small amount of water and 2×20 ml of diethyl ether
  3. customAfter drying

Sources & evidence

ORD record
ord-f6121370a1524fabb1be1694dd32627f
Source dataset
uspto-grants-2000_06
Patent number
US06080743

Reaction notes

Loading…