Hydrogen Bromide → HCID 18706506, compound

HRID 1422236Notes

Reaction equation

HRID 1422236 reaction equation
Cl.Cl.C[O:4][C:5]1[C:14]([O:15]C)=[N:13][C:12]2[C:7](=[CH:8][C:9]([N+:30]([O-:32])=[O:31])=[CH:10][C:11]=2[CH2:17][N:18]([CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][N:25]=2)[CH2:19][C:20]([OH:22])=[O:21])[N:6]=1.[BrH:33]>C(O)(=O)C.C(OCC)C>[BrH:33].[BrH:33].[O:4]=[C:5]1[C:14](=[O:15])[NH:13][C:12]2[C:7](=[CH:8][C:9]([N+:30]([O-:32])=[O:31])=[CH:10][C:11]=2[CH2:17][N:18]([CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][N:25]=2)[CH2:19][C:20]([OH:22])=[O:21])[NH:6]1

Participants

5

Reactant 2

HCID 260Hydrogen BromideHCID 18706334HCID 18706334, compound

Product 1

HCID 18706506HCID 18706506, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 3283Diethyl EtherSolvent

Procedure

49 mg (0.1 mmol) of N-(2,3-dimethoxy-7-nitro-quinoxalin-5-ylmethyl)-N-(2-pyridylmethyl)-glycine dihydrochloride are stirred in 2 ml of a 48% solution of hydrogen bromide in acetic acid for 18 hours at 70° C. The mixture is diluted with diethyl ether and the solid is filtered off, washed with diethyl ether and dried. The title compound is obtained in the form of a yellow solid.

Workup

  1. filtrationthe solid is filtered off
  2. washwashed with diethyl ether
  3. customdried

Sources & evidence

ORD record
ord-5a6ebc185bcd4816966ddc15b099a881
Source dataset
uspto-grants-2000_06
Patent number
US06080743

Reaction notes

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