1-Isocyanato-4-methoxybenzene → N-(2,3-Dimethoxy-7-nitro-quinoxalin-5-ylmethyl)-3-(4-methoxyphenyl)-urea

HRID 1422242Notes

Reaction equation

HRID 1422242 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]=[C:10]=[O:11])=[CH:5][CH:4]=1.[NH2:12][CH2:13][C:14]1[CH:23]=[C:22]([N+:24]([O-:26])=[O:25])[CH:21]=[C:20]2[C:15]=1[N:16]=[C:17]([O:29][CH3:30])[C:18]([O:27][CH3:28])=[N:19]2>COC(C)(C)C>[CH3:28][O:27][C:18]1[C:17]([O:29][CH3:30])=[N:16][C:15]2[C:20](=[CH:21][C:22]([N+:24]([O-:26])=[O:25])=[CH:23][C:14]=2[CH2:13][NH:12][C:10]([NH:9][C:6]2[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=2)=[O:11])[N:19]=1

Participants

4

Reactant 2

HCID 794431-Isocyanato-4-methoxybenzeneHCID 179152965-Aminomethyl-2,3-dimethoxy-7-nitro-quinoxaline

Product 1

HCID 18706390N-(2,3-Dimethoxy-7-nitro-quinoxalin-5-ylmethyl)-3-(4-methoxyphenyl)-urea

Reagents, catalysts & solvents 1

HCID 15413tert-Butyl methyl etherSolvent

Procedure

62 mg (0.416 mmol) of 4-methoxyphenyl isocyanate are added at room temperature to a suspension of 100 mg (0.379 mmol) of 5-aminomethyl-2,3-dimethoxy-7-nitro-quinoxaline in 2 ml of tert-butyl methyl ether, and the mixture is stirred for 3 hours. The suspension is then filtered off, and the filter residue is washed with tert-butyl methyl ether and dried under a high vacuum. The title compound is obtained in the form of a beige solid.

Workup

  1. filtrationThe suspension is then filtered off
  2. washthe filter residue is washed with tert-butyl methyl ether
  3. customdried under a high vacuum

Sources & evidence

ORD record
ord-ed344f4bc5b44e428135d22421f243a0
Source dataset
uspto-grants-2000_06
Patent number
US06080743

Reaction notes

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