HCID 53822033, compound → HCID 18706611, compound

HRID 1422254Notes

Reaction equation

HRID 1422254 reaction equation
C([O:5][C:6](=[O:27])[CH2:7][O:8][CH2:9][C:10]1[CH:19]=[C:18]([N+:20]([O-:22])=[O:21])[CH:17]=[C:16]2[C:11]=1[N:12]=[C:13]([O:25]C)[C:14]([O:23]C)=[N:15]2)(C)(C)C>Br.C(O)(=O)C.C(OCC)C>[O:23]=[C:14]1[C:13](=[O:25])[NH:12][C:11]2[C:16](=[CH:17][C:18]([N+:20]([O-:22])=[O:21])=[CH:19][C:10]=2[CH2:9][O:8][CH2:7][C:6]([OH:27])=[O:5])[NH:15]1

Participants

5

Reactant 1

HCID 53822033HCID 53822033, compound

Product 1

HCID 18706611HCID 18706611, compound

Reagents, catalysts & solvents 3

HCID 176Acetic AcidSolventHCID 260Hydrogen BromideSolventHCID 3283Diethyl EtherSolvent

Procedure

270 mg (0.711 mmol) of 2-(2,3-dimethoxy-7-nitro-quinoxalin-5-ylmethoxy)-acetic acid tert-butyl ester are dissolved in 6 ml of an approximately 16% hydrogen bromide solution in acetic acid and the solution is stirred at room temperature for 20 hours. The reaction mixture is diluted with diethyl ether and the solid is filtered off, washed with diethyl ether and dried. The title compound is obtained in the form of a solid (m.p.>300° C.).

Workup

  1. filtrationthe solid is filtered off
  2. washwashed with diethyl ether
  3. customdried

Sources & evidence

ORD record
ord-433a3ae838ce498c84c868000116316d
Source dataset
uspto-grants-2000_06
Patent number
US06080743

Reaction notes

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