4-Aminopyridine → HCID 18706378, compound

HRID 1422257Notes

Reaction equation

HRID 1422257 reaction equation
[Br:1][CH2:2][C:3]1[CH:12]=[C:11]([N+:13]([O-:15])=[O:14])[CH:10]=[C:9]2[C:4]=1[N:5]=[C:6]([O:18][CH3:19])[C:7]([O:16][CH3:17])=[N:8]2.[NH2:20][C:21]1[CH:26]=[CH:25][N:24]=[CH:23][CH:22]=1>ClCCl.C(#N)C>[Br-:1].[NH2:20][C:21]1[CH:26]=[CH:25][N+:24]([CH2:2][C:3]2[CH:12]=[C:11]([N+:13]([O-:15])=[O:14])[CH:10]=[C:9]3[C:4]=2[N:5]=[C:6]([O:18][CH3:19])[C:7]([O:16][CH3:17])=[N:8]3)=[CH:23][CH:22]=1

Participants

5

Reactant 2

HCID 17274-AminopyridineHCID 232979835-Bromomethyl-7-nitro-2,3-dimethoxyquinoxaline

Product 1

HCID 18706378HCID 18706378, compound

Reagents, catalysts & solvents 2

HCID 6342AcetonitrileSolventHCID 6344DichloromethaneSolvent2×

Procedure

A solution of 197 mg (0.6 mmol) of 5-bromomethyl-2,3-dimethoxy-7-nitro-quinoxaline in 2 ml of dichloromethane is added at room temperature to a suspension of 282 mg (3 mmol) of 4-aminopyridine in 1 ml of dichloromethane and 3 ml of acetonitrile and the mixture is then stirred for 3.5 hours at room temperature. The resulting precipitate is filtered off and then washed on the filter with a small amount of acetonitrile. The title compound is obtained in the form of a colorless powder.

Workup

  1. filtrationThe resulting precipitate is filtered off
  2. washwashed on the
  3. filtrationfilter with a small amount of acetonitrile

Sources & evidence

ORD record
ord-ea766e3055e5459bb36a2567fcc4acb8
Source dataset
uspto-grants-2000_06
Patent number
US06080743

Reaction notes

Loading…