HCID 53972305, compound → HCID 18706349, compound

HRID 1422264Notes

Reaction equation

HRID 1422264 reaction equation
C([O:3][C:4](=[O:33])[C:5]([NH:29]C(=O)C)([CH2:11][C:12]1[CH:21]=[C:20]([N+:22]([O-:24])=[O:23])[CH:19]=[C:18]2[C:13]=1[N:14]=[C:15]([O:27]C)[C:16]([O:25]C)=[N:17]2)C(OCC)=O)C>Cl>[NH2:29][CH:5]([CH2:11][C:12]1[CH:21]=[C:20]([N+:22]([O-:24])=[O:23])[CH:19]=[C:18]2[C:13]=1[NH:14][C:15](=[O:27])[C:16](=[O:25])[NH:17]2)[C:4]([OH:33])=[O:3]

Participants

3

Reactant 1

HCID 53972305HCID 53972305, compound

Product 1

HCID 18706349HCID 18706349, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A suspension of 0.29 g (0.62 mmol) of 2-acetylamino-2-(2,3-dimethoxy-7-nitro-quinoxalin-5-ylmethyl)-malonic acid diethyl ester in 6 ml of 6N hydrochloric acid is heated at reflux for 24 hours and then concentrated to dryness under reduced pressure. After boiling the residue up with water, centrifugation and drying, the title compound is obtained in the form of a yellow powder.

Workup

  1. temperatureis heated
  2. temperatureat reflux for 24 hours
  3. concentrationconcentrated to dryness under reduced pressure
  4. customdrying

Sources & evidence

ORD record
ord-20076c0fe7de44d6a9c5164ec1c40976
Source dataset
uspto-grants-2000_06
Patent number
US06080743

Reaction notes

Loading…