4-Methoxyphenol → HCID 18779299, compound

HRID 1422305Notes

Reaction equation

HRID 1422305 reaction equation
[Cl-].[CH2:2]([P+:6]([CH2:16][CH2:17][CH2:18][CH3:19])([CH2:12][CH2:13][CH2:14][CH3:15])[CH2:7][CH2:8][CH2:9][CH2:10][OH:11])[CH2:3][CH2:4][CH3:5].COC1C=CC(O)=CC=1.[C:29]([Cl:34])(=[O:33])[C:30]([CH3:32])=[CH2:31]>C(#N)C>[Cl-:34].[CH2:12]([P+:6]([CH2:2][CH2:3][CH2:4][CH3:5])([CH2:16][CH2:17][CH2:18][CH3:19])[CH2:7][CH2:8][CH2:9][CH2:10][O:11][C:29](=[O:33])[C:30]([CH3:32])=[CH2:31])[CH2:13][CH2:14][CH3:15]

Participants

5

Reactant 3

HCID 90154-MethoxyphenolHCID 13528Methacryloyl chlorideHCID 18779301HCID 18779301, compound

Product 1

HCID 18779299HCID 18779299, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Into a 1 L-four-necked flask equipped with a stirrer, a thermometer and a distillation line, was added the obtained tri-n-butyl(4-hydroxybutyl)phosphonium chloride dissolved in 500 ml of acetonitrile. The solution was heated under a normal pressure while stirring and about 200 ml of acetonitrile was distilled. A condenser having a calcium chloride tube was installed, 1.5 g of hydroquinone monomethyl ether was added as a polymerization inhibitor, and 70.5 g (0.674 mol) of methacryloyl chloride was added thereto dropwise at 50° C. over 2 hours through a dropping funnel, then the solution was maturated for 3 hours at the same temperature.

Workup

  1. customInto a 1 L-four-necked flask equipped with a stirrer
  2. temperatureThe solution was heated under a normal pressure
  3. distillationabout 200 ml of acetonitrile was distilled
  4. customA condenser having
  5. customa calcium chloride tube was installed
  6. additionwas added
  7. waitthe solution was maturated for 3 hours at the same temperature

Sources & evidence

ORD record
ord-d0ba7bdb5af841ab99ebde84b031f70c
Source dataset
uspto-grants-2000_06
Patent number
US06080885

Reaction notes

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