反应详情

2-Benzyloxy-3-methylbenzaldehyde prepared by the above 2-(1) 20.0 g (88.4 mmol) was dissolved in methanol 100 ml and thereto was added sulfuric acid 20.0 g (203 mmol) and then added 30% hydrogen peroxide 30.1 g (265 mmol). The mixture was refluxed for 2 hours. After disappearance of the raw material, the solution was concentrated in vacuo, neutralized with a saturated sodium bicarbonate solution and extracted with methylene chloride. The solvent was removed in vacuo and the residue was purified by silica gel chromatography (n-hexane-ethyl acetate) to give 2-benzyloxy-3-methylphenol 13.3 g (yield: 70%).

1. temperatureThe mixture was refluxed for 2 hours
2. concentrationAfter disappearance of the raw material, the solution was concentrated in vacuo
3. extractionextracted with methylene chloride
4. customThe solvent was removed in vacuo
5. customthe residue was purified by silica gel chromatography (n-hexane-ethyl acetate)