Cyclohexyl isocyanate → HCID 47448389, compound

HRID 1422401Notes

Reaction equation

HRID 1422401 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[CH2:7][NH2:8])([O-:3])=[O:2].[CH:12]1([N:18]=[C:19]=[O:20])[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1>C1COCC1>[CH:12]1([NH:18][C:19]([NH:8][CH2:7][C:6]2[CH:9]=[CH:10][CH:11]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=2)=[O:20])[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1

Participants

4

Reactant 2

HCID 18502Cyclohexyl isocyanateHCID 1227223-Nitrobenzylamine

Product 1

HCID 47448389HCID 47448389, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

3-Nitro-benzyl-amine (5 g) was suspended in THF (130 ml) and cyclohexyl isocyanate (7 ml) was added dropwise at 25° C. After stirring for 2 h the resulting precipitate was filtered off, washed with diethyl ether and treated with 5% aqueous NH4OH. After filtering and drying the title compound was isolated (4.5 g, FP 168-169° C.)

Workup

  1. filtrationwas filtered off
  2. washwashed with diethyl ether
  3. additiontreated with 5% aqueous NH4OH
  4. filtrationAfter filtering
  5. dry with materialdrying the title compound
  6. customwas isolated (4.5 g, FP 168-169° C.)

Sources & evidence

ORD record
ord-3c173824aedf43eeb1ee8ee43750704b
Source dataset
uspto-grants-2015_01
Patent number
USRE045323E1

Reaction notes

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