反应详情

温度

50 °C

10 mg of 3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(14),11(15),12-triene (48.5 μmol) are dissolved in a water-acetonitrile mixture (170 μl of acetonitrile and 7 μl of water). After the addition of 10 μl of TEA (1.4 eq), the mixture is heated to 50° C. and then 13 mg of ethyl bromoglutarate (1 eq) are added. The medium is stirred at 50° C. for 18 h.