Water → HCID 65312554, compound

In a 1 liter round bottom flask with magnetic stir bar, serinol (10.0 g) and Na2CO3 (25.0 g) were dissolved in the mixture of DI water (250 mL) and THF (150 mL). The reaction mixture was allowed to cool in ice. Ethyl chloroformate (10.5 mL) was added drop-wise and the reaction was allowed to proceed in ice for 4 hours, followed by about 16 hours at room temperature. Another 100 mL of DI water was added to the reaction mixture and the product was extracted into ethyl acetate (20×100 mL). The crude product (11.6 g) was further purified by flash column chromatography, using silica as the packing material and CH3OH:CHCl3 (1:9) mixture as the eluent. The final product was a transparent viscous oil that was crystallized in the presence of trace ethyl acetate (1 to 2 mL) along with vigorous scratching using a spatula. The crystallized product was washed with cold ethyl acetate:hexanes (1:1) mixture (1×100 mL), and dried under vacuum to result in white crystalline solid (8.9 g, 54.5%).

1. temperatureto cool in ice
2. waitfollowed by about 16 hours at room temperature
3. extractionthe product was extracted into ethyl acetate (20×100 mL)
4. customThe crude product (11.6 g) was further purified by flash column chromatography
5. customwas crystallized in the presence of trace ethyl acetate (1 to 2 mL) along
6. washThe crystallized product was washed with cold ethyl acetate:hexanes (1:1) mixture (1×100 mL)
7. customdried under vacuum

ORD record

ord-aea5550f13f74c2b856993cca9edc0f2

Source dataset

uspto-grants-2015_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08926998B2