Dichloromethane → Ethyl 5-bromo-3-(tetrahydro-2H-thiopyran-4-yl)-1H-indole-7-carboxylate

HRID 142245Notes

Reaction equation

HRID 142245 reaction equation
[Br:8][c:9]1[cH:10][c:11]2[cH:12][cH:13][nH:14][c:15]2[c:16]([C:18](=[O:19])[O:20][CH2:21][CH3:22])[cH:17]1.[CH2:23]([SiH:24]([CH2:25][CH3:26])[CH2:27][CH3:28])[CH3:29].[Cl:30][CH2:31][Cl:32].[S:1]1[CH2:2][CH2:3][C:4](=[O:7])[CH2:5][CH2:6]1>>[S:1]1[CH2:2][CH2:3][CH:4]([c:12]2[c:11]3[cH:10][c:9]([Br:8])[cH:17][c:16]([C:18](=[O:19])[O:20][CH2:21][CH3:22])[c:15]3[nH:14][cH:13]2)[CH2:5][CH2:6]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 12052TriethylsilaneHCID 66173Tetrahydrothiopyran-4-oneHCID 59332585Ethyl 5-bromo-1H-indole-7-carboxylate

Product 1

HCID 59332655Ethyl 5-bromo-3-(tetrahydro-2H-thiopyran-4-yl)-1H-indole-7-carboxylate

Sources & evidence

ORD record
ord-76b7f371305e463a9c61c295a9946d7a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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