HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tyramine → 4-(2-(6-chloro-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)ethyl)phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tyramine | HCID 5610 | — |
| Reactant | 6-Chloro-2-iodo-9-isopropyl-9H-purine | HCID 6538904 | — |
| Reactant | 4,6-dichloro-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidine | HCID 42609352 | — |
| Product | 4-(2-(6-chloro-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)ethyl)phenol | HCID 86643461 | — |
Reaction Steps
Following the procedure of Example 128b, 4,6-dichloro-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidine (U.S. Pat. No. 3,399,196) (a) (0.184 g, 0.795 mmol) was reacted with tyramine. The crude residue was purified by silica gel chromatography (25 to 75% ethyl acetate in hexane eluant) to afford the title compound as a solid. MS m/z 332.1 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08927281B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-7650ba7e2716462bad044cf604363702 |
| Source note | uspto-grants-2015_01 |