Isopropyl iodide → HCID 72208044, compound

HRID 1422485Notes

Reaction equation

HRID 1422485 reaction equation
[Cl:1][C:2]1[N:3]=[C:4]([Cl:11])[C:5]2[CH:10]=[CH:9][NH:8][C:6]=2[N:7]=1.I[CH:13]([CH3:15])[CH3:14]>>[Cl:1][C:2]1[N:3]=[C:4]([Cl:11])[C:5]2[CH:10]=[CH:9][N:8]([CH:13]([CH3:15])[CH3:14])[C:6]=2[N:7]=1

Participants

3

Reactant 2

HCID 6362Isopropyl iodideHCID 141168712,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine

Product 1

HCID 72208044HCID 72208044, compound

Procedure

Following the procedure of Example 15b, 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine (0.5 g, 2.67 mmol) was reacted with 2-iodopropane. The crude residue was purified by silica gel chromatography (15 to 25% ethyl acetate in hexane eluant) to afford the title compound as a solid. MS m/z 230.2 (M+1).

Workup

  1. customThe crude residue was purified by silica gel chromatography (15 to 25% ethyl acetate in hexane eluant)

Sources & evidence

ORD record
ord-2c44590765da43feb1e2242d60338787
Source dataset
uspto-grants-2015_01
Patent number
US08927281B2

Reaction notes

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