Isopropyl iodide → 4,6-Dichloro-1-(1-methylethyl)-1H-imidazo[4,5-c]pyridine

HRID 1422495Notes

Reaction equation

HRID 1422495 reaction equation
[Cl:1][C:2]1[C:7]2[N:8]=[CH:9][NH:10][C:6]=2[CH:5]=[C:4]([Cl:11])[N:3]=1.I[CH:13]([CH3:15])[CH3:14]>>[Cl:1][C:2]1[C:7]2[N:8]=[CH:9][N:10]([CH:13]([CH3:15])[CH3:14])[C:6]=2[CH:5]=[C:4]([Cl:11])[N:3]=1

Participants

3

Reactant 2

HCID 6362Isopropyl iodideHCID 53585624,6-dichloro-1H-imidazo[4,5-c]pyridine

Product 1

HCID 866434674,6-Dichloro-1-(1-methylethyl)-1H-imidazo[4,5-c]pyridine

Procedure

Following the procedure of Example 15b, 4,6-dichloro-1H-imidazo[4,5-c]pyridine (J. Het. Chem. 1965, 196-201) (0.19 g, 1.0 mmol) was reacted with 2-iodopropane. The residue was purified by silica gel chromatography (25 to 35% ethyl acetate in hexane eluant) to afford the title compound as a solid. MS m/z 230.2 (M+1).

Workup

  1. customThe residue was purified by silica gel chromatography (25 to 35% ethyl acetate in hexane eluant)

Sources & evidence

ORD record
ord-f090278e3d2b47048189da376a0d9857
Source dataset
uspto-grants-2015_01
Patent number
US08927281B2

Reaction notes

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