4H,5H,6H,7H-(1,3)thiazolo(5,4-c)pyridine → {(S)-6-[(R)-4-(6,7-Dihydro-thiazolo[5,4-c]pyridin-5-ylmethyl)-5-trifluoromethyl-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester

HRID 1422634노트

반응식

HRID 1422634 반응식
[CH3:1][O:2][C:3](=[O:30])[CH2:4][C@H:5]1[C:9]2[CH:10]=[CH:11][C:12]([O:14][C@H:15]3[C:23]4[C:18](=[C:19]([CH2:28]Br)[C:20]([C:24]([F:27])([F:26])[F:25])=[CH:21][CH:22]=4)[CH2:17][CH2:16]3)=[CH:13][C:8]=2[O:7][CH2:6]1.[N:31]1[C:39]2[CH2:38][CH2:37][NH:36][CH2:35][C:34]=2[S:33][CH:32]=1>>[CH3:1][O:2][C:3](=[O:30])[CH2:4][C@H:5]1[C:9]2[CH:10]=[CH:11][C:12]([O:14][C@H:15]3[C:23]4[C:18](=[C:19]([CH2:28][N:36]5[CH2:37][CH2:38][C:39]6=[N:31][CH2:32][S:33][C:34]6=[CH:35]5)[C:20]([C:24]([F:27])([F:26])[F:25])=[CH:21][CH:22]=4)[CH2:17][CH2:16]3)=[CH:13][C:8]=2[O:7][CH2:6]1

참가 물질

3

반응물 2

HCID 219419924H,5H,6H,7H-(1,3)thiazolo(5,4-c)pyridineHCID 86700813{(S)-6-[(R)-4-Bromomethyl-5-trifluoromethyl-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester

생성물 1

HCID 90313454{(S)-6-[(R)-4-(6,7-Dihydro-thiazolo[5,4-c]pyridin-5-ylmethyl)-5-trifluoromethyl-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester

실험 절차

The title compound is prepared from {(S)-6-[(R)-4-bromomethyl-5-trifluoromethyl-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester and 4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridine following a procedure analogous to that described for Intermediate 42. LC (method 1): tR=1.16 min; Mass spectrum (ESI+): m/z=545 [M+H]+.

출처 및 근거

ORD 기록
ord-2dd6de7abafd42c7b48e350cf4cbbd68
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08927531B2

반응 노트

불러오는 중…