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HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 1422634Erstellt: 26. Oktober 2026

4H,5H,6H,7H-(1,3)thiazolo(5,4-c)pyridine → {(S)-6-[(R)-4-(6,7-Dihydro-thiazolo[5,4-c]pyridin-5-ylmethyl)-5-trifluoromethyl-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester

https://huagongshe.com/reaction/1422634

Reaktionsgleichung

Beteiligte Stoffe

RolleNameHCIDEinwaage
Edukt4H,5H,6H,7H-(1,3)thiazolo(5,4-c)pyridineHCID 21941992—
Edukt{(S)-6-[(R)-4-Bromomethyl-5-trifluoromethyl-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl esterHCID 86700813—
Produkt{(S)-6-[(R)-4-(6,7-Dihydro-thiazolo[5,4-c]pyridin-5-ylmethyl)-5-trifluoromethyl-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl esterHCID 90313454—

Reaktionsschritte

The title compound is prepared from {(S)-6-[(R)-4-bromomethyl-5-trifluoromethyl-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester and 4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridine following a procedure analogous to that described for Intermediate 42. LC (method 1): tR=1.16 min; Mass spectrum (ESI+): m/z=545 [M+H]+.

Herkunft & Nachweise

DOI10.6084/m9.figshare.5104873.v1
PatentnummerUS08927531B2
Quelldatensatzuspto-grants-2015_01
ORD IDord-2dd6de7abafd42c7b48e350cf4cbbd68
Quellennotizuspto-grants-2015_01