2-Methyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-C]pyridine → {(S)-6-[(R)-4-(2-Methyl-2,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-ylmethyl)-5-trifluoromethyl-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester

HRID 1422635노트

반응식

HRID 1422635 반응식
[CH3:1][O:2][C:3](=[O:30])[CH2:4][C@H:5]1[C:9]2[CH:10]=[CH:11][C:12]([O:14][C@H:15]3[C:23]4[C:18](=[C:19]([CH2:28]Br)[C:20]([C:24]([F:27])([F:26])[F:25])=[CH:21][CH:22]=4)[CH2:17][CH2:16]3)=[CH:13][C:8]=2[O:7][CH2:6]1.[CH3:31][N:32]1[CH:40]=[C:35]2[CH2:36][NH:37][CH2:38][CH2:39][C:34]2=[N:33]1>>[CH3:1][O:2][C:3](=[O:30])[CH2:4][C@H:5]1[C:9]2[CH:10]=[CH:11][C:12]([O:14][C@H:15]3[C:23]4[C:18](=[C:19]([CH2:28][N:37]5[CH2:38][CH2:39][C:34]6=[N:33][N:32]([CH3:31])[CH:40]=[C:35]6[CH2:36]5)[C:20]([C:24]([F:27])([F:26])[F:25])=[CH:21][CH:22]=4)[CH2:17][CH2:16]3)=[CH:13][C:8]=2[O:7][CH2:6]1

참가 물질

3

반응물 2

HCID 159087732-Methyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-C]pyridineHCID 86700813{(S)-6-[(R)-4-Bromomethyl-5-trifluoromethyl-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester

생성물 1

HCID 90313806{(S)-6-[(R)-4-(2-Methyl-2,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-ylmethyl)-5-trifluoromethyl-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester

실험 절차

The title compound is prepared from {(S)-6-[(R)-4-bromomethyl-5-trifluoromethyl-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester and 2-methyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine following a procedure analogous to that described for Intermediate 42. LC (method 1): tR=0.92 min; Mass spectrum (ESI+): m/z=542 [M+H]+.

출처 및 근거

ORD 기록
ord-6ea8fca482a34274b22f4c00fa0af9c4
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08927531B2

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