HRID1422635

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID15908773

2-Methyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine

C7H11N3

结构：COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c3ccc(C(F)(F)F)c4CBr)ccc21

HCID86700813

未命名化合物

PRODUCTS

生成物

结构：COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c3ccc(C(F)(F)F)c4CN3CCc4nn(C)cc4C3)ccc21

HCID90313806

未命名化合物

PROCEDURE

实验过程

The title compound is prepared from {(S)-6-[(R)-4-bromomethyl-5-trifluoromethyl-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester and 2-methyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine following a procedure analogous to that described for Intermediate 42. LC (method 1): tR=0.92 min; Mass spectrum (ESI+): m/z=542 [M+H]+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6ea8fca482a34274b22f4c00fa0af9c4
来源数据集: uspto-grants-2015_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08927531B2
来源说明: uspto-grants-2015_01

反应 SMILES

[CH3:1][O:2][C:3](=[O:30])[CH2:4][C@H:5]1[C:9]2[CH:10]=[CH:11][C:12]([O:14][C@H:15]3[C:23]4[C:18](=[C:19]([CH2:28]Br)[C:20]([C:24]([F:27])([F:26])[F:25])=[CH:21][CH:22]=4)[CH2:17][CH2:16]3)=[CH:13][C:8]=2[O:7][CH2:6]1.[CH3:31][N:32]1[CH:40]=[C:35]2[CH2:36][NH:37][CH2:38][CH2:39][C:34]2=[N:33]1>>[CH3:1][O:2][C:3](=[O:30])[CH2:4][C@H:5]1[C:9]2[CH:10]=[CH:11][C:12]([O:14][C@H:15]3[C:23]4[C:18](=[C:19]([CH2:28][N:37]5[CH2:38][CH2:39][C:34]6=[N:33][N:32]([CH3:31])[CH:40]=[C:35]6[CH2:36]5)[C:20]([C:24]([F:27])([F:26])[F:25])=[CH:21][CH:22]=4)[CH2:17][CH2:16]3)=[CH:13][C:8]=2[O:7][CH2:6]1