2-Bromoethanol → HCID 66747614, compound

HRID 1422790Notes

Reaction equation

[CH2:1]([O:3][C:4]([C@H:6]1[C@@H:11]([NH:12][C:13]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[O:14])[CH2:10][CH2:9][NH:8][CH2:7]1)=[O:5])[CH3:2].Br[CH2:24][CH2:25][OH:26].Cl[C:28]1[CH:37]=[N:36][C:35]2[C:30](=[CH:31][C:32]([O:38][CH3:39])=[CH:33][CH:34]=2)[N:29]=1>>[CH2:1]([O:3][C:4]([C@H:6]1[C@@H:11]([NH:12][C:13]([O:15][CH2:16][C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)=[O:14])[CH2:10][CH2:9][N:8]([CH2:24][CH2:25][O:26][C:28]2[CH:37]=[N:36][C:35]3[C:30](=[CH:31][C:32]([O:38][CH3:39])=[CH:33][CH:34]=3)[N:29]=2)[CH2:7]1)=[O:5])[CH3:2]

Participants

Reactant 3

HCID 108982-Bromoethanol

HCID 126864152-Chloro-7-methoxyquinoxaline

HCID 66746359HCID 66746359, compound

Product 1

HCID 66747614HCID 66747614, compound

Procedure

The title compound is prepared as a yellow oil following Scheme 1 and in analogy to Example 1 using (3R,4S)-4-benzyloxycarbonylamino-piperidine-3-carboxylic acid ethyl ester (prepared according to procedures described in WO2005/066176), 2-bromo-ethanol and 2-chloro-7-methoxy-quinoxaline as starting materials.

Sources & evidence

ORD record: ord-15e3cb71026f45bbbc6c3f9036d62b97
Source dataset: uspto-grants-2015_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08927542B2

Reaction notes

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