反应详情

温度

58 °C

Bromoacetic acid (0.876 g, 6.31 mmol, 0.5 eq) is added portionwise to 3,4-dimethoxy-2-nitro-phenylamine (2.5 g, 12.61 mmol, 1.0 eq) and the mixture is stirred at 58° C. for 16 hours. The reaction is then quenched by 25% ammonia in water and diluted with water. The solid is filtered off and washed with 10% ammonia in water. The combined solutions are acidified by concentrated hydrochloric acid and the resulting precipitate is collected by filtration, washed with water and dried under vacuum to afford (3,4-dimethoxy-2-nitro-phenylamino)-acetic acid as a red solid (1.1 g, 34% yield).

1. customThe reaction is then quenched by 25% ammonia in water
2. additiondiluted with water
3. filtrationThe solid is filtered off
4. washwashed with 10% ammonia in water
5. filtrationthe resulting precipitate is collected by filtration
6. washwashed with water
7. customdried under vacuum