Hydrazine hydrate (1:1) → HCID 178438827, compound

HRID 1422854Notes

Reaction equation

HRID 1422854 reaction equation
C1(O[C:8](=[O:23])[NH:9][C:10]2[CH:11]=[C:12]3[C:16](=[CH:17][CH:18]=2)[CH2:15][C:14]2([O:22][CH2:21][CH2:20][O:19]2)[CH2:13]3)C=CC=CC=1.[OH2:24].[NH2:25][NH2:26].[O:27]1[CH2:32][CH2:31]OCC1>>[CH2:15]1[C:16]2[C:12](=[CH:11][C:10]([N:9]3[C:8]([OH:23])=[N:26][N:25]=[C:16]3[C:12]3[CH:11]=[C:31]([CH:18]([CH3:17])[CH3:10])[C:32]([OH:27])=[CH:14][C:13]=3[OH:24])=[CH:18][CH:17]=2)[CH2:13][C:14]21[O:19][CH2:20][CH2:21][O:22]2

Participants

4

Reactant 3

HCID 24654Hydrazine hydrate (1:1)HCID 312751,4-DioxaneHCID 68751858HCID 68751858, compound

Product 1

HCID 178438827HCID 178438827, compoundYield 77%

Conditions

Temperature
100 °C

Procedure

To a solution of (1′,3′-Dihydro-spiro[[1,3]dioxolane-2,2′-inden]-5′-yl)-carbamic acid phenyl ester in dioxane (20 mL) was added hydrazine hydrate (1.26 mL, 26 mmol) and the reaction mixture was stirred at 100° C. for 1 h. Solvent was removed under vacuum and then water was added. Precipitated solid was filtered and dried to give the title product as an off-white solid (1.0 g, 77%).

Workup

  1. customSolvent was removed under vacuum
  2. additionwater was added
  3. customPrecipitated solid
  4. filtrationwas filtered
  5. customdried

Sources & evidence

ORD record
ord-92ef47c7c0e0472a9cbbfa217a08afa6
Source dataset
uspto-grants-2015_01
Patent number
US08927548B2

Reaction notes

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