HCID 178489978, Verbindung → 4-[2-(3,4-Dimethoxy-phenyl)-ethyl]-6-[5-hydroxy-4-(1-methyl-1H-indol-5-yl)-4H-[1,2,4]triazol-3-yl]-benzene-1,3-diol

HRID 1422861Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1422861
C([O:8][C:9]1[CH:14]=[C:13]([O:15]CC2C=CC=CC=2)[C:12]([CH:23]=[CH:24][C:25]2[CH:30]=[CH:29][C:28]([O:31][CH3:32])=[C:27]([O:33][CH3:34])[CH:26]=2)=[CH:11][C:10]=1[C:35]1[N:36]([C:41]2[CH:42]=[C:43]3[C:47](=[CH:48][CH:49]=2)[N:46]([CH3:50])[CH:45]=[CH:44]3)[C:37]([OH:40])=[N:38][N:39]=1)C1C=CC=CC=1>[Pd].CO>[CH3:34][O:33][C:27]1[CH:26]=[C:25]([CH2:24][CH2:23][C:12]2[CH:11]=[C:10]([C:35]3[N:36]([C:41]4[CH:42]=[C:43]5[C:47](=[CH:48][CH:49]=4)[N:46]([CH3:50])[CH:45]=[CH:44]5)[C:37]([OH:40])=[N:38][N:39]=3)[C:9]([OH:8])=[CH:14][C:13]=2[OH:15])[CH:30]=[CH:29][C:28]=1[O:31][CH3:32]

Komponenten

4

Edukt 1

HCID 178489978HCID 178489978, Verbindung

Produkt 1

HCID 1784899774-[2-(3,4-Dimethoxy-phenyl)-ethyl]-6-[5-hydroxy-4-(1-methyl-1H-indol-5-yl)-4H-[1,2,4]triazol-3-yl]-benzene-1,3-diolAusbeute 88 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A flask was charged with 5-{2,4-bis-benzyloxy-5-[2-(3,4-dimethoxy-phenyl)-vinyl]-phenyl}-4-(1-methyl-1H-indol-5-yl)-4H-[1,2,4]triazol-3-ol (164 mg; 0.25 mmol), 10% palladium on carbon (50 mg); methanol (20 mL), and place under an atmosphere of hydrogen. The reaction was stirred overnight, and then filtered through celite. The solvent was removed to give 4-[2-(3,4-Dimethoxy-phenyl)-ethyl]-6-[5-hydroxy-4-(1-methyl-1H-indol-5-yl)-4H-[1,2,4]triazol-3-yl]-benzene-1,3-diol (109 mg; 0.22 mmol).

Aufarbeitung

  1. filtrationfiltered through celite
  2. customThe solvent was removed

Quellen und Nachweise

ORD-Eintrag
ord-9c8c832987b1497ab83f10dfdfa74df9
Quelldatensatz
uspto-grants-2015_01
Patentnummer
US08927548B2

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