反应详情

A suspension of 3-Methyluracil (3.0 mg, 23.8 mmol), isobutyl iodide (7 mL, 60 mmol) and cesium carbonate (11.6 g, 35.7 mmol) in DMF (30 mL) is stirred at room temperature over a weekend. Solvent is removed under vacuum. The residue is treated with water, and then extracted with dichloromethane four times. The combined organic phase is washed with brine, dried over anhydrous sodium sulfate, and then filtered through a short silica gel column. The filtrate is concentrated to dryness to give product as off white solids, which is used for the next reaction without further purification. MS (ESI) m/z 183.1 [M+H]+.

1. customSolvent is removed under vacuum
2. additionThe residue is treated with water
3. extractionextracted with dichloromethane four times
4. washThe combined organic phase is washed with brine
5. dry with materialdried over anhydrous sodium sulfate
6. filtrationfiltered through a short silica gel column
7. concentrationThe filtrate is concentrated to dryness
8. customto give product as off white solids, which
9. customis used for the next reaction without further purification