HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1423004Generated: November 1, 2026
Aniline → 6-((4-Pyridin-2yl)-benzyl)-1-isobutyl-3-methyl-5-(phenylamino)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione
https://huagongshe.com/reaction/1423004
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Aniline | HCID 6115 | — |
| Reactant | HCID 67416103 | HCID 67416103 | — |
| Product | 6-((4-Pyridin-2yl)-benzyl)-1-isobutyl-3-methyl-5-(phenylamino)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione | HCID 46234277 | 46% |
Reaction Steps
Crude 5-chloro-1-isobutyl-3-methyl-6-(4-(pyridin-2-yl)benzyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione (0.032 mmol) is placed in a Biotage microwave tube, and then aniline (0.2 mL) is added. The mixture is heated at 150° C. for an hour, and then purified by a semi-preparative HPLC to give 7 mg of pure product (overall yield:46%). MS (ESI) m/z 480.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08927556B2 |
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| Source dataset | uspto-grants-2015_01 |
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| ORD ID | ord-c9a8ab2fb86a4e0a848a8a7c6d07133d |
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| Source note | uspto-grants-2015_01 |
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