HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1423008Generated: November 1, 2026
Aniline → 1-isobutyl-6-(4-methoxybenzyl)-3,7-dimethyl-5-(phenylamino)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione
https://huagongshe.com/reaction/1423008
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Aniline | HCID 6115 | — |
| Reactant | 5-chloro-1-isobutyl-6-(4-methoxybenzyl)-3,7-dimethyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione | HCID 68624950 | — |
| Product | 1-isobutyl-6-(4-methoxybenzyl)-3,7-dimethyl-5-(phenylamino)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione | HCID 46234431 | — |
Reaction Steps
5-chloro-1-isobutyl-6-(4-methoxybenzyl)-3,7-dimethyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione (12 mg, 0.03 mmol) is placed in a Biotage microwave tube, and then aniline (0.22 mL) is added. The mixture was heated at 150° C. for 3 h., and then purified by a semi-preparative HPLC to give 4 mg of pure product. MS (ESI) m/z 447.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08927556B2 |
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| Source dataset | uspto-grants-2015_01 |
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| ORD ID | ord-56948c7180b94923b48975de6cb18475 |
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| Source note | uspto-grants-2015_01 |
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