Dimethylformamide dimethyl acetal → 2102885-50-5

Participants

Reaction Steps

A mixture of the 4,4-diethoxy-3-oxo-butyric acid ethyl ester (0.500 g, 2.29 mmol, prepared according to the procedure described in JACS, 1919, 41, 812) and dimethylformamide dimethyl acetal (370 μL, 2.78 mmol) in xylenes (5.0 mL) is warmed at reflux. After 30 minutes, The reaction mixture is concentrated in vacuo to afford 2-[1-dimethylamino-meth-(Z)-ylidene]-4,4-diethoxy-3-oxo-butyric acid ethyl ester, which is used in the next step without purification.

Provenance & Evidence