Dimethylformamide dimethyl acetal → 2102885-50-5

HRID 1423015Notes

Reaction equation

HRID 1423015 reaction equation
[CH2:1]([O:3][C:4](=[O:15])[CH2:5][C:6](=[O:14])[CH:7]([O:11][CH2:12][CH3:13])[O:8][CH2:9][CH3:10])[CH3:2].CO[CH:18](OC)[N:19]([CH3:21])[CH3:20]>>[CH2:1]([O:3][C:4](=[O:15])/[C:5](=[CH:18]\[N:19]([CH3:21])[CH3:20])/[C:6](=[O:14])[CH:7]([O:8][CH2:9][CH3:10])[O:11][CH2:12][CH3:13])[CH3:2]

Participants

3

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 11138577Ethyl 4,4-diethoxy-3-oxobutanoate

Product 1

HCID 873054892102885-50-5

Procedure

A mixture of the 4,4-diethoxy-3-oxo-butyric acid ethyl ester (0.500 g, 2.29 mmol, prepared according to the procedure described in JACS, 1919, 41, 812) and dimethylformamide dimethyl acetal (370 μL, 2.78 mmol) in xylenes (5.0 mL) is warmed at reflux. After 30 minutes, The reaction mixture is concentrated in vacuo to afford 2-[1-dimethylamino-meth-(Z)-ylidene]-4,4-diethoxy-3-oxo-butyric acid ethyl ester, which is used in the next step without purification.

Workup

  1. customprepared
  2. temperatureis warmed
  3. temperatureat reflux
  4. concentrationThe reaction mixture is concentrated in vacuo

Sources & evidence

ORD record
ord-faccbf69d7a746d585b5207c01bd3fdf
Source dataset
uspto-grants-2015_01
Patent number
US08927550B2

Reaction notes

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