反应详情

Chloroacetaldehyde (45% aqueous solution) (6.6 mL, 38 mmol) is added to the stirred solution of 2-aminonicotinic acid (5.0 g, 25 mmol) in ethanol (35 mL) and warmed at reflux for 14 hours. The reaction mixture is concentrated and the crude material is triturated with EtOH-Et2O to afford imidazo[1,2-a]pyridine-8-carboxylic acid. Mp: 296-299° C.

1. temperaturewarmed
2. temperatureat reflux for 14 hours
3. concentrationThe reaction mixture is concentrated
4. customthe crude material is triturated with EtOH-Et2O