HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroacetaldehyde → Imidazo[1,2-a]pyridine-8-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroacetaldehyde | HCID 33 | — |
| Reactant | 2-Aminonicotinic acid | HCID 72930 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Imidazo[1,2-a]pyridine-8-carboxylic acid | HCID 11715357 | — |
Reaction Steps
Chloroacetaldehyde (45% aqueous solution) (6.6 mL, 38 mmol) is added to the stirred solution of 2-aminonicotinic acid (5.0 g, 25 mmol) in ethanol (35 mL) and warmed at reflux for 14 hours. The reaction mixture is concentrated and the crude material is triturated with EtOH-Et2O to afford imidazo[1,2-a]pyridine-8-carboxylic acid. Mp: 296-299° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08927550B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-765518d27083414d94bc6a3d51089fa6 |
| Source note | uspto-grants-2015_01 |