反应详情

温度

120 °C

To a solution of 1-(2-bromo-thiazol-5-yl)-propan-1-one (75 mg, 0.34 mmol) in DMSO (3 mL) is added sodium methanesulfonate (41 mg, 0.34 mmol) followed by copper (I) iodide (65 mg, 0.34 mmol). The mixture is warmed in a microwave reactor at 120° C. After 1 hour, the reaction is diluted with EtOAc (20 mL) and washed with saturated aqueous sodium bicarbonate (50 mL) and brine (10 mL). The aqueous phase is extracted with EtOAc (2×10 mL). The combined organic layers are dried over magnesium sulfate, filtered and concentrated to afford 1-(2-methanesulfonyl-thiazol-5-yl)-propan-1-one which is used without further purification.

1. washwashed with saturated aqueous sodium bicarbonate (50 mL) and brine (10 mL)
2. extractionThe aqueous phase is extracted with EtOAc (2×10 mL)
3. dry with materialThe combined organic layers are dried over magnesium sulfate
4. filtrationfiltered
5. concentrationconcentrated