참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium methanesulfonate | HCID 638112 | — |
| 반응물 | 1-(2-Bromothiazol-5-yl)propan-1-one | HCID 59278085 | — |
| 촉매 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 1-(2-Methanesulfonyl-thiazol-5-yl)-propan-1-one | HCID 59278397 | — |
반응 단계
To a solution of 1-(2-bromo-thiazol-5-yl)-propan-1-one (75 mg, 0.34 mmol) in DMSO (3 mL) is added sodium methanesulfonate (41 mg, 0.34 mmol) followed by copper (I) iodide (65 mg, 0.34 mmol). The mixture is warmed in a microwave reactor at 120° C. After 1 hour, the reaction is diluted with EtOAc (20 mL) and washed with saturated aqueous sodium bicarbonate (50 mL) and brine (10 mL). The aqueous phase is extracted with EtOAc (2×10 mL). The combined organic layers are dried over magnesium sulfate, filtered and concentrated to afford 1-(2-methanesulfonyl-thiazol-5-yl)-propan-1-one which is used without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08927550B2 |
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| 출처 데이터셋 | uspto-grants-2015_01 |
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| ORD ID | ord-744a587cad594eac8fb372a0d157d933 |
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| 출처 메모 | uspto-grants-2015_01 |
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